Calories in Starbucks Caramel Frappuccino with semi-skimmed milk run 270 to 387 calories by size, identical to the standard and low-fat versions — “semi-skimmed” is the British English term for the same milk US menus call low-fat.
A Grande comes to 346 calories with fat at 15.8g and protein at 5g, no different from any other naming of this drink. Only the whole milk version runs meaningfully higher, adding roughly 2g of fat per size.
For the American-labeled equivalents, both lactose-free and low-fat milk pages carry the same numbers.
Caramel Frappuccino® - semi-skimmed milk Nutrition Facts
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Caramel Frappuccino® - semi-skimmed milk
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Long-Term Health Impact
After 1 Week
Drinking a daily Grande Caramel Frappuccino® - semi-skimmed milk adds 2422 calories to your week — about 466 minutes of brisk walking to offset.
After 1 Month
Over a month, that's 10380 calories — roughly 3.0 lb of potential weight gain if it isn't offset by activity.
After 1 Year
Over a year, a daily Grande Caramel Frappuccino® - semi-skimmed milk totals 126290 calories and 16.0kg of sugar — equivalent to about 1263 miles of jogging to burn off.

